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KMID : 0370220220660060316
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Yakhak Hoeji
2022 Volume.66 No. 6 p.316 ~ p.323
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Ameliorating Effect of Lespedeza cuneata Extract on Male Menopause in Wistar Rats by Increasing Androgen Receptor
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Lee Seong
Choung Se-Young
Kim Chang-Hee
Kim Hyung-Jee
Mo Sang-Joon
Choi Sun-Hyang
Kim Eun-Young
Kang Da-Hye
Kim Eun-Jin
Ahn Jin-Chul
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Abstract
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Male menopause, also referred to as late-onset hypogonadism or andropause, is a clinical syndromecharacterized by sexual dysfunction, depressive disorder, and insomnia secondary to a testosterone deficiency in older men.
Lespedeza cuneata, which belongs to the Fabaceae family, possesses several biological properties, including antiinflammatory,anti-oxidant, and antidiabetic effects. We investigated the inhibitory effect of standardized L. cuneata extract(LCE) on andropause symptoms in vivo. LCE administration significantly increased serum levels of total testosteronewithout any effects on serum estrogen levels. Additionally, LCE significantly increased serum 17-beta hydroxysteroiddehydrogenase 13 protein levels and reduced levels of sex hormone-binding globulin (SHBG), a protein that blocks freetestosterone movement into the cytosol. LCE significantly upregulated the expression of cAMP response element bindingprotein and androgen receptor (AR), which functions as a transcription factor to stimulate spermatogenesis-associated genesand results in increased numbers of AR-positive cells, such as Leydig and Sertoli cells in the testis. To summarize, LCEadministration increases serum testosterone, reduces SHBG levels and upregulates AR expression. Therefore, LCE may beuseful as alternative therapy for andropause in older men.
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KEYWORD
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Androgen receptor, Andropause, Male menopause, Lespedeza cuneata, Testosterone
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